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Review Article 
NMJ. 2015; 4(1): 12-24


Induced pluripotent stem cell and their applications in Drug Discovery and Precision Personalized Medicine

Dr. Mahaboob V Shaik1 Dr. Subrahmanyam G2.

Abstract
The ever improving technology to generate induced pluripotent stem cells (iPSCs) has increased their potential
use as novel candidates for disease modeling, drug screening, regenerative medicine and cell therapy. Scientists
can derive iPSCs from the skin, blood, various other cell sources from affected patients and then convert
them into the cell types involved in the patientís disease. This process could allow researchers to study the
development of a disease in a petridish, with the advantage of having a potentially endless supply of new
cells. Ultimately, the goal of scientists as well as pharmaceutical companies is to use these petridish models
to better understand the disease process and identify novel drugs to treat the disease. The result of this
promising field may be the more rapid development of drugs from which millions could benefit. Because
pluripotent cells are capable of generating any type of tissue in the body, the application of iPSCs therapy to
treat various diseases. This technique also offers the possibility of repairing disease-causing genetic mutations
before reintroducing the new cells, an approach that has been used with adult stem cells to treat leukemia
and lymphoma. Patient-specific iPSC-derived cellular transplantation should also avoid the immune response
since these cells are autologous. This review focuses on the applications of iPSCs with special respect to
updates of drug discovery, personalized medicine and cell therapy.

Key words: Keywords: Induced pluripotent stem cell; Drug discovery; Disease modeling; Precision personalized medicine.


 
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Pubmed Style

Dr. Mahaboob V Shaik Dr. Subrahmanyam G. Induced pluripotent stem cell and their applications in Drug Discovery and Precision Personalized Medicine. NMJ. 2015; 4(1): 12-24.


Web Style

Dr. Mahaboob V Shaik Dr. Subrahmanyam G. Induced pluripotent stem cell and their applications in Drug Discovery and Precision Personalized Medicine. http://www.narayanamedicaljournal.com/?mno=196241 [Access: January 08, 2022].


AMA (American Medical Association) Style

Dr. Mahaboob V Shaik Dr. Subrahmanyam G. Induced pluripotent stem cell and their applications in Drug Discovery and Precision Personalized Medicine. NMJ. 2015; 4(1): 12-24.



Vancouver/ICMJE Style

Dr. Mahaboob V Shaik Dr. Subrahmanyam G. Induced pluripotent stem cell and their applications in Drug Discovery and Precision Personalized Medicine. NMJ. (2015), [cited January 08, 2022]; 4(1): 12-24.



Harvard Style

Dr. Mahaboob V Shaik Dr. Subrahmanyam G (2015) Induced pluripotent stem cell and their applications in Drug Discovery and Precision Personalized Medicine. NMJ, 4 (1), 12-24.



Turabian Style

Dr. Mahaboob V Shaik Dr. Subrahmanyam G. 2015. Induced pluripotent stem cell and their applications in Drug Discovery and Precision Personalized Medicine. Narayana Medical Journal, 4 (1), 12-24.



Chicago Style

Dr. Mahaboob V Shaik Dr. Subrahmanyam G. "Induced pluripotent stem cell and their applications in Drug Discovery and Precision Personalized Medicine." Narayana Medical Journal 4 (2015), 12-24.



MLA (The Modern Language Association) Style

Dr. Mahaboob V Shaik Dr. Subrahmanyam G. "Induced pluripotent stem cell and their applications in Drug Discovery and Precision Personalized Medicine." Narayana Medical Journal 4.1 (2015), 12-24. Print.



APA (American Psychological Association) Style

Dr. Mahaboob V Shaik Dr. Subrahmanyam G (2015) Induced pluripotent stem cell and their applications in Drug Discovery and Precision Personalized Medicine. Narayana Medical Journal, 4 (1), 12-24.








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