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Short Communication 


Assessment of booster vaccination with hepatitis B vaccine using predominant usage of TCR VĪ² genes

Jianwei Zhou, Yizhao Li, Yu Li.

Abstract
Background: Seroconcentraion of Hepatitis B surface antibody titers (anti-HBs) is always used to assess the protectvie effets of HBV vaccination. In this study, the usage of variable region of beta chain genes of T cell receptor (TCR VĪ²) is taken as an index to estimate the function of booster vaccnation of HBV vaccine.
Subjects and Methods: 11 students whose seroconcentration of anti-HBs was less than 10 mIU/ml were recruited. 3 month later after one dose of booster vaccination with HBV vaccine, the level of anti-HBs and predominant usage of TCR VĪ² was detected with chemiluminescence method and agarose gel electrophoresis technique, respectively.
Results: After booster vaccination, the average concentration of anti-HBs of ten vaccinees was 143.7±28.5 mIU/ml, which was significantly higher than that before vaccination (P<0.0001); the ratio of predominantly used TCR VĪ² genes was 21.2% (55/260), and it was significantly higher than that of before booster vaccination (11.9%, P<0.01).
Conclusion: TCR VĪ² could be taken as an index to estimate the effect of HBV vaccination.

Key words: Booster vaccination, Hepatitis B surface antibody, T cell receptor


 
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How to Cite this Article
Pubmed Style

Zhou J, Li Y, Li Y, . Assessment of booster vaccination with hepatitis B vaccine using predominant usage of TCR Vβ genes. NMJ. 2021; 10(1): 52-54. doi:10.5455/nmj./00000203


Web Style

Zhou J, Li Y, Li Y, . Assessment of booster vaccination with hepatitis B vaccine using predominant usage of TCR Vβ genes. http://www.narayanamedicaljournal.com/?mno=72332 [Access: June 18, 2021]. doi:10.5455/nmj./00000203


AMA (American Medical Association) Style

Zhou J, Li Y, Li Y, . Assessment of booster vaccination with hepatitis B vaccine using predominant usage of TCR Vβ genes. NMJ. 2021; 10(1): 52-54. doi:10.5455/nmj./00000203



Vancouver/ICMJE Style

Zhou J, Li Y, Li Y, . Assessment of booster vaccination with hepatitis B vaccine using predominant usage of TCR Vβ genes. NMJ. (2021), [cited June 18, 2021]; 10(1): 52-54. doi:10.5455/nmj./00000203



Harvard Style

Zhou, J., Li, Y., Li, Y. & (2021) Assessment of booster vaccination with hepatitis B vaccine using predominant usage of TCR Vβ genes. NMJ, 10 (1), 52-54. doi:10.5455/nmj./00000203



Turabian Style

Zhou, Jianwei, Yizhao Li, Yu Li, and . 2021. Assessment of booster vaccination with hepatitis B vaccine using predominant usage of TCR Vβ genes. Narayana Medical Journal, 10 (1), 52-54. doi:10.5455/nmj./00000203



Chicago Style

Zhou, Jianwei, Yizhao Li, Yu Li, and . "Assessment of booster vaccination with hepatitis B vaccine using predominant usage of TCR Vβ genes." Narayana Medical Journal 10 (2021), 52-54. doi:10.5455/nmj./00000203



MLA (The Modern Language Association) Style

Zhou, Jianwei, Yizhao Li, Yu Li, and . "Assessment of booster vaccination with hepatitis B vaccine using predominant usage of TCR Vβ genes." Narayana Medical Journal 10.1 (2021), 52-54. Print. doi:10.5455/nmj./00000203



APA (American Psychological Association) Style

Zhou, J., Li, Y., Li, Y. & (2021) Assessment of booster vaccination with hepatitis B vaccine using predominant usage of TCR Vβ genes. Narayana Medical Journal, 10 (1), 52-54. doi:10.5455/nmj./00000203








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