Open Access and Peer-reviewed
Home Journal Issues Guide for Authors Editorial Board Aims & Scope About Journal News & Announcements


Original Article 


COMPARISON OF A 3-DRUG MIXTURE vs. DEXMEDETOMIDINE FOR ATTENUATION OF STRESS RESPONSE DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION

Sai Sudha L, Ashalatha P, Krishna Chaitanya K.

Abstract
OBJECTIVE:
To compare the anaesthetic effects of a 3-drug mixture IV Magnesium sulphate, IV Dexamethasone, IV Loxicard ; and IV Dexmedetomidine in suppressing the hemodynamic stress response to laryngoscopy and endotracheal intubation.
MATERIALS AND METHODS:
60 patients were divided into two equal groups of 30 in each group were enrolled in this study. GROUP M received 1g MgSO4, 8mg dexamethasone, 1.5mg/kg Loxicard in 100ml NS given over 10mins (n=30) GROUP D received 1mcg/kg dexmedetomidine in 100ml NS given over 10 mins (n=30) ; prior to induction of anaesthesia. Both the groups were observed for changes in hemodynamic parameters like HR, SBP, DBP at 0, 1, 3, 5, 10 minutes after laryngoscopy and intubation.
RESULTS:
Comparison of both the groups reveals that HR response post intubation was better attenuated with dexmedetomidine with statistically significant p values at all time intervals. Attenuation of blood pressure with dexmedetomidine at 0,1 min post intubation had statistically significant p values (SBP at 0min(p-0.003) ,1 min(p-0.01) and DBP at 0min(p-0.04), 1min(p-0.04) , whereas there was no statistically significant difference in blood pressure at 3,5,10 minutes post intubation between both the groups.
CONCLUSION:
The increase in heart rate was better attenuated with dexmedetomidine and blood pressure was as effectively attenuated with the 3-drug mixture when compared to dexmedetomidine. Hence, this mixture can be used as an effective and safe alternative to dexmedetomidine.

Key words: Stress response, Dexmedetomidine, 3-drug mixture, heart rate, blood pressure, laryngoscopy, intubation.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Sai Sudha L
Articles by Ashalatha P
Articles by Krishna Chaitanya K
on Google
on Google Scholar
Article Statistics
 Viewed: 300
Downloaded: 20


How to Cite this Article
Pubmed Style

L SS, P A, K KC, . COMPARISON OF A 3-DRUG MIXTURE vs. DEXMEDETOMIDINE FOR ATTENUATION OF STRESS RESPONSE DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION. NMJ. 2019; 8(2): 64-71. doi:10.5455/nmj./00000169


Web Style

L SS, P A, K KC, . COMPARISON OF A 3-DRUG MIXTURE vs. DEXMEDETOMIDINE FOR ATTENUATION OF STRESS RESPONSE DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION. http://www.narayanamedicaljournal.com/?mno=77377 [Access: January 26, 2020]. doi:10.5455/nmj./00000169


AMA (American Medical Association) Style

L SS, P A, K KC, . COMPARISON OF A 3-DRUG MIXTURE vs. DEXMEDETOMIDINE FOR ATTENUATION OF STRESS RESPONSE DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION. NMJ. 2019; 8(2): 64-71. doi:10.5455/nmj./00000169



Vancouver/ICMJE Style

L SS, P A, K KC, . COMPARISON OF A 3-DRUG MIXTURE vs. DEXMEDETOMIDINE FOR ATTENUATION OF STRESS RESPONSE DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION. NMJ. (2019), [cited January 26, 2020]; 8(2): 64-71. doi:10.5455/nmj./00000169



Harvard Style

L, S. S., P, A., K, K. C. & (2019) COMPARISON OF A 3-DRUG MIXTURE vs. DEXMEDETOMIDINE FOR ATTENUATION OF STRESS RESPONSE DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION. NMJ, 8 (2), 64-71. doi:10.5455/nmj./00000169



Turabian Style

L, Sai Sudha, Ashalatha P, Krishna Chaitanya K, and . 2019. COMPARISON OF A 3-DRUG MIXTURE vs. DEXMEDETOMIDINE FOR ATTENUATION OF STRESS RESPONSE DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION. Narayana Medical Journal, 8 (2), 64-71. doi:10.5455/nmj./00000169



Chicago Style

L, Sai Sudha, Ashalatha P, Krishna Chaitanya K, and . "COMPARISON OF A 3-DRUG MIXTURE vs. DEXMEDETOMIDINE FOR ATTENUATION OF STRESS RESPONSE DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION." Narayana Medical Journal 8 (2019), 64-71. doi:10.5455/nmj./00000169



MLA (The Modern Language Association) Style

L, Sai Sudha, Ashalatha P, Krishna Chaitanya K, and . "COMPARISON OF A 3-DRUG MIXTURE vs. DEXMEDETOMIDINE FOR ATTENUATION OF STRESS RESPONSE DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION." Narayana Medical Journal 8.2 (2019), 64-71. Print. doi:10.5455/nmj./00000169



APA (American Psychological Association) Style

L, S. S., P, A., K, K. C. & (2019) COMPARISON OF A 3-DRUG MIXTURE vs. DEXMEDETOMIDINE FOR ATTENUATION OF STRESS RESPONSE DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION. Narayana Medical Journal, 8 (2), 64-71. doi:10.5455/nmj./00000169








AUTHOR LOGIN

REVIEWER LOGIN

Indexed
&
Abstracted


Google Scholar, Index Copernicus,Index Scholar,DOAJ(Directory of Open access Journals),COSMOS


ABOUT JOURNAL
POLICIES
STATEMENTS

This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. This is in accordance with the Budapest Open Access Initiative (BOAI) definition of open access.

The articles in Narayana Medical Journal are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.